Agilent 6420 QQQ LCMS System

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The Agilent 6420 triple quadrupole LC/MS System is designed to offer exemplary sensitivity, in a reliable, robust, single point of control of partnered LC/MS and HPLC systems. Built with state of the art components and orthogonal ionization technology, this triple quad LC/MS is low cost to operate, and offers a fast solution for simultaneous quantifying, screening and confirming analyses using triggered MRm, as well as dynamic multiple reaction monitoring. The MRM function of this triple quad LC/MS helps users avoid false positives with confirmation of compound identification, and reports high sensitivity on each ion transition acquired. The Dynamic MRM function groups MRMs in a time window instead of individual segments and has the ability to quantify up to 4000 compounds, giving users more powerful quantitative methods and robust information.

The Agilent 6420 triple quadrupole LC/MS System is ideal for fields needing quantitative analysis such as forensics, toxicology, food testing, clinical research, pharmaceutical ADME/DMPK studies, and environmental analysis. This LC/MS System is also built for round the clock use, to support labs that need to process large numbers of samples. The updated electronics of this LC/MS System gives you high speed data acquisition, and speedy polarity switching for positive and negative ion analysis. The Agilent 6420 Triple Quadrupole LC/MS System is a reliable go to instrument for those laboratories needing standard quantitative capabilities.  This LC/MS System has a hyperbolic quadrupole design, a high-pressure hexapole collision cell with linear acceleration and an off-axis high energy dynode detector.

This Agilent 6420 triple quadrupole LC/MS system is partnered with an Agilent 1290 Liquid Chromatograph, built to provide high speed, high resolution and high sensitivity, for both UHPLC and HPLC applications. The Agilent 1290 LC combines ultra-high pressure up to 1200 bar, with high flow rates up to 5ml per minute, making it an extremely flexible, compatible and high performing LC and LC/MS solution. The Agilent 1290 LC System uses a Diode Array Detector that reaches new levels of Uv/Vis sensitivity.  If you're looking for something a little more robust with higher sensitivity, please check out our Agilent 6460 LCMS - ClLICK HERE

Agilent G6420AA Triple Quadrupole LC/MS System:

Mass range

m/z 5 – 2,250

Polarity switching

30 ms

Mass accuracy

0.1 Da from 5 – 1,000 m/z 0.01% from 1,000 – 2,000 m/z 0.02% from 2,000 – 2,250 m/z

Mass stability

< 0.1 Da in 24 h

Dynamic range

> 6.0 × 106

Scan modes

MS scan, MS/MS product ion scan, MRM, MS/MS neutral loss/gain scan and precursor ion scan, SIM

Maximum scan rate

12,500 Da/s

Minimum MRM dwell time

1 ms

MRM transitions

450 per time segment, > 40,000 ion transitions per method

Dynamic MRM transitions

4,000 ion transitions per method

Triggered MRM transitions

Up to 10 MRM transitions (primary and secondary) for library search and compound confirmation

Collision cell ion clearance

< 1 ms

Single point of control


Single-point data system method capability with full control of Agilent 1200 Series HPLC systems and the 6420A Triple Quadrupole LC/MS System

Time programming

• Polarity change in time segment • Scan and SIM or MRM (plus other modes of data collection) • Dynamic and triggered MRM aligns MRMs with compound retention time • Solvent divert through calibrant delivery system valve

Wide range of ionization sources

• Electrospray (ESI) • Nanospray with HPLC-Chip Cube MS interface • APCI source (Atmospheric Pressure Chemical Ionization) • Multimode source (simultaneous ESI and APCI) • APPI source (Atmospheric Pressure Photo Ionization)


Automated optimization of ion optics and mass axis calibration in positive and negative ion modes using a proprietary tune solution

Solvent declustering

Countercurrent gas


High-energy conversion dynode and high-gain electron multiplier horn

Vacuum system

One turbomolecular pump with one mechanical pump


240V 60/50Hz  

Dimensions (Agilent G6420AA)

44” x 25” x 30”


242 lb

  • Agilent 6420A Triple Quadrupole LC/MS
  • Agilent 1290/1260 Infinity HPLC Components:
  • G1367E HIP ALS
  • G1316 TCC 
  • G1312 Binary Pump
  • G4225A Vacuum Degasser
  • G1312B Binary Pump
  • Agilent Solvent Tray
  • Windows 7 Computer Workstation with Agilent Mass Hunter and LabAdvisor
  • Universal Trap RMSN-2
  • Universal Trap RMSN-4
  • Agilent Rotary Vane Vacuump Pump with Vacuum Hose
  • Used Copper Capillary for Trap
  • Waste Bottle with Hose
  • Multistage Regulator
  • All Required Communication & Power Cables
  • One Year Service Contact (Installation Required)
  • Nitrogen Generator SOLD SEPARATELY.

This listing is for a 2015 Agilent LCMS System.  The Agilent 6420 Triple Quadrupole LC/MS system just came off of lease and is still under a service agreement.   We're offering for almost a third of the price and comes with a laundry list of accessories.  Contact us today with questions about this gently used Agilent LCMS System.

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