Agilent 1100 HPLC System

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The Agilent 1100 Series LC System provides you with in depth molecular information in a modular instrument that’s easy to maintain and intuitive to use. This Capillary LC system brings you a complete analytical solution, with fully integrated hardware and software to boost your productivity and give you results of which you can be confident. This Liquid Chromatography System consists of a Multi Wavelength Detector, quat pump, thermostated column compartment, autosampler, and a vacuum degasser. The Agilent 1100 Series LC lets you analyze a broad spectrum of compounds such as proteins and peptides, pesticides and herbicides, as well as drugs and drug metabolites. This LC system helps shorten analysis times, while providing robust information such as molecular weight, structure, low level impurities, and quantitative information without the need for fully resolved peaks, letting you do more in a single run with less preparation.


The Agilent 1100 Series LC lets you use existing HPLC methods through an orthogonal-spray ion source and high-capacity drying gas system for exceptional sensitivity and reproducibility. The benefits of the orthogonal spray of this LC system are reduced background and ion source contamination, optimized desolvation and ion transport, and it eliminates the need to reposition for changes to flow rate or solvent compositions. The Agilent 1100 Series LC also comes equipped with Agilent Lab Advisor Software, with instrument tests for daily use, general calibration tools, and maintenance procedures.

Agilent 1100 HPLC System Component Specifications:

Thermostated Autosampler


Temperature Range

4-40°C in 1° increments

MWD Detector


Detection type

1024-element photodiode array

Light source

Deuterium and tungsten lamps

Wavelength range

190 – 950 nm

Short term noise (ASTM) Single and Multi-Wavelength

Typically ± 3 × 10-5 AU at 254 nm at flow rates 100 µl/min For the 500 nl flow cell the noise is 2-3 times higher than with standard flow cell


2 × 10-3 AU/hr at 254 nm

Linear absorbance range

> 2 AU (upper limit)

Wavelength accuracy

± 1 nm Self-calibration with deuterium lines, verification with holmium oxide filter

Wavelength bunching

1 – 400 nm Programmable in steps of 1 nm

Slit width

1, 2, 4 , 8, 16 nm Programmable slit

Diode width

 < 1 nm

Flow cell

500 nanoliter: 0.5 µl volume, 10 mm cell path length and 50 bar (725 psi) pressure maximum

Maximum pressure

50 bar

Thermostated Column Compartment


Temperature range

10 degrees below ambient to 80 °C

Temperature stability

± 0.15 °C

Column capacity Three

25 cm -

Warm-up/cool-down time

5 minutes from ambient to 40 °C 10 minutes from 40 – 20 °C

Internal volume

3 µl left heat exchanger 6 µl right heat exchanger

Vacuum Degasser


Flow rate

10 ml/min per channel

Number of channels


Internal volume per channel

Typically 12 ml per channel

Materials in contact with solvent


pH range

1 – 14

Analog output (AUX)

For pressure monitoring, range 0 – 3 V

Quart  Pump


Hydraulic system

Dual plunger in series pump with proprietary servo-controlled variable stroke drive, floating plungers and active inlet valve

Setable flow range

0.001 – 10 ml/min, in 0.001 ml/min increments

Flow range

0.2 – 10.0 ml/min

Flow accuracy

± 1% or 10 µl/min whatever is greater

Pressure Operating Range

0 – 40 MPa (0 – 400 bar, 0 – 5880 psi) up to 5 ml/min

Operating range

0 – 20 MPa (0 – 200 bar, 0 – 2950 psi) up to 10 ml/min

Recommended pH range


1.0 – 12.5, solvents with pH < 2.3 should not contain acids which attack stainless steel

ALS Auto Sampler


Injection range

 0.1 – 100 µl in 0.1 µl increments

Replicate injections

1 – 99 from one vial


< 0.25% RSD from 5 – 100 µl, < 1% RSD 1 – 5 µl variable volume

Minimum sample volume

1 µl from 5 µl sample in 100 µl microvial, or 1 µl from 10 µl sample in 300 µl microvial

Carryover Typically

< 0.1%, < 0.05% with external needle cleaning

Sample viscosity range

0.2 – 50 cp

Replicate injections per vial

1 – 99

Sample capacity

100 × 2-ml vials in 1 tray 40 × 2-ml vials in ½ tray 15 × 6-ml vials in ½ tray Agilent vials only)

Injection cycle time

Typically 50 s depending on draw speed and injection volume



  • Agilent 1100 HPLC with Following Modules:
  • G1365B MWD Detector
  • G1329A ALS Autosampler
  • G1330A ALS Thermostat
  • G1316C Colcom 
  • G1322A Vacuum Degasser
  • G1311 Quat Pump
  • Windows Notebook with Software
  • System Validation Reports with Clean Bill of Health
  • CAN Cables
  • Operator's Guide
  • 115V Power Cables
  • 30-Day Warranty

This  Agilent 1100 Series LC System has been fully tested and comes with a clean bill of health. All of our lab equipment comes backed with our standard warranty. Should you have any questions, please don't hesitate to contact us.

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